Keto Diet: How Adipose Can Impact It
By Tom Seest
At BestKetoNews, we save you time and resources by curating relevant information and news about the keto / ketogenic diet.
A keto diet is a low-carb, high-fat eating plan designed to switch your body over from carbohydrates to using fat as fuel instead. Studies have demonstrated its success in helping individuals lose weight quickly while improving blood sugar control in the short term.
Some individuals report feeling better on a keto diet compared to other diets; however, before embarking on one it’s advisable to speak to a registered dietitian nutritionist first.
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Adipose tissue is a specialized connective tissue comprised of energy-storing cells called adipocytes and other cells such as fibroblasts and blood vessels. It can be found all throughout the body, from subcutaneous fat under the skin (subcutaneous fat) to organs, muscles, bone marrow, and breast tissue.
Normal functioning adipose tissue stores your energy as large globules of fat called “lipid droplets,” providing warmth by protecting organs like your heart from cold temperatures.
Your body responds to stress, physical exertion, or starvation by breaking down stored fatty acids and glycerol from adipose tissue into energy-rich fuel for other parts of your body – this process, known as lipolysis, is initiated by specific hormones including epinephrine, norepinephrine, glucagon, and adrenocorticotropin.
Lipid droplets are then stored in adipocytes and distributed among connective tissue septa into lobules formed by connective tissue septa, where they form lobules that contain them. When viewing microscopic images of white adipose tissue, each adipocyte contains one single fatty lipid droplet filled with one cell wall lipid; these are organized into lobules surrounded by an extracellular matrix composed of reticular fibers and non-residential cells such as inflammatory cells.
Adipose tissue does more than store energy; it also serves an important endocrine function by secreting various bioactive factors that regulate metabolic function, including growth factors and cytokines that help manage metabolism. Two key adiponectin and leptin hormones play this role.
These endocrine hormones are produced in adipose tissue and circulated throughout the body to other metabolically active organs, including the liver, pancreas, and muscles. Their impact can be felt across many key metabolic processes like glucose homeostasis, fatty acid metabolism, and sex hormone metabolism.
On a keto diet, your body begins using fat as its primary energy source instead of glucose; previously, it relied on food sources for this energy source; when glucose becomes scarcer through food alone, your body enters ketosis mode.
Ketosis occurs when your body uses fat for fuel instead of carbohydrates or proteins; the production of ketones helps meet energy demands for other areas, such as your brain. Ketosis is a natural process, and your body usually adjusts fairly quickly.
Your body can only produce so many ketones on its own; your diet provides the rest. Therefore, those on a low-carb, high-fat diet often experience what’s known as “keto flu” during their initial days on such a diet: fatigued, weak, lightheadedness, and “brain fog” as they adapt to this new fuel source.
Adipose tissue serves many important purposes, including insulation and the production of pads between organs, as well as hormone secretion and other biological factors. Therefore, it’s vitally important that healthy levels of adipose tissue be maintained, as failure to do so could result in obesity as well as related medical conditions like type 2 diabetes mellitus.
Adipose tissue, also known as connective fat tissue, stores and releases energy through storage and release mechanisms. This type of loose connective tissue can be found underneath the skin (subcutaneous fat), around organs (visceral fat), and in bone marrow cavities (bone marrow adipose tissue).
Adipose tissue is commonly recognized for storing energy, but it also serves as an endocrine organ by producing bioactive molecules that interact with other organs and regulate metabolic functions. A dysfunction in this organ may lead to obesity, metabolic syndrome, or diabetes as a result.
White and brown adipose tissue differ in their structure, function, and location. White adipose tissue is most prevalent among mammals and serves to store energy while also functioning as a thermal insulator to maintain body temperature.
Brown adipose tissue serves a different function – creating heat. This type of fat is commonly seen in newborns and hibernating mammals to keep their bodies warm during hibernation periods.
Adipocytes, or fat cells, are the main cell types found within adipose tissue. They store and release lipids through lipolysis – which is initiated when hormones bind to adipocytes and activate lipase – an enzyme that hydrolyzes triacylglycerol to release energy-rich fatty acids and glycerol as waste products.
Adipose tissue produces several hormones, such as adiponectin, leptin, resistin, and plasminogen activator inhibitor-1. These hormones can impact the amount of fat stored or released and help control blood sugar levels.
Homeostasis in adipose tissue means that its number of adipocytes doesn’t fluctuate with changes to body weight; as its amount increases with body mass increase, however, the size of its cells expands accordingly.
Adipose tissue can be found throughout the body in various anatomical locations. The distribution can differ among individuals, which may affect how their bodies respond to diet and exercise programs.
Adipose tissue serves many important purposes beyond simply protecting organs, such as providing insulation, being an important source of hormones, and producing bioactive compounds.
Adipose tissue amounts vary among people depending on gender, age, and genetics; those with white adipose tissue have an increased risk for heart disease and diabetes than those who possess lower percentages.
To successfully shed unwanted fat, it is crucial that you consume an appropriate balance of healthy foods while limiting your intake of saturated and trans-fats, which not only make you hungry but can also lower metabolism and cause weight gain – particularly from sources such as hydrogenated oils or margarine that contain excessive levels of trans fats.
Adipose tissue is a complex network of lipid-filled mature adipocytes and precursor stem cells surrounded by an extracellular matrix and richly supplied with blood vessels and nerve fibers, with abundant blood supply coming through blood vessels in our bodies and an extracellular matrix providing protection. Although it may appear passive at first glance, adipose tissue plays a vital role in our overall well-being, and an active role within it is essential.
Adipose (aka fat tissue) is the part of the body that stores excess energy (fat). These fat stores are used to generate heat, protect organs, and maintain body temperatures during extreme situations; additionally, they act as insulation and cushioning around soft tissues in our bodies.
Fat is composed primarily of adipocytes but may also include pre-adipocytes, fibroblasts, blood vessels, and inflammatory cells. Fat cells can be found all throughout the body but primarily around organs (visceral fat) or under the skin (subcutaneous fat).
Adipocytes are specialized cells with one lipid droplet containing several organelles and serve several roles, including energy storage, organ protection, and the secretion of hormones.
Adipose contains many other cells, such as stromal vascular fraction (SVF) cells and mast cells, that produce and release various cytokines to regulate energy balance in the body, hunger/satisfaction/metabolism/inflammatory responses, and overall inflammation response.
White Adipose Tissue (WAT) and Brown Adipose Tissue (BAT). WAT can typically be found around the liver and in skeletal muscle areas in the abdominal region; BAT, on the other hand, tends to accumulate around the chest area near the heart and elsewhere in the body.
Both types of adipose contain abundant supplies of type III collagen-containing reticular fibers that give shape and stability to their respective tissue types, as well as numerous blood vessels and unmyelinated nerve fibers.
Your liver has the capacity to store large quantities of energy that it will use when your body requires an increase in energy. Furthermore, when stored carbohydrates or fatty acids run low on reserves for fueling energy production in your system, it also has the capacity to burn fats when you run short on other forms of energy storage like carbohydrates and fatty acids.
Adipose tissue has the unique capability of producing and releasing specific bioactive molecules that communicate with other tissues, for instance dysfunctional adipose tissue produces extracellular vesicles that travel directly to the brain causing cognitive impairment.
At first glance, fat may seem like the enemy; however, this tissue actually plays an essential role in supporting health and function in our bodies.
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